They are very hostile and tend to attack the player on sight.
- For some unknown reason, brains can not move through open trapdoors. However, they can still shoot through them.
- Try to cover the bottom half of the brain in dirt, thus trapping it and making its gun useless.
- A brain's shield can withstand any gun. Long periods of gunfire causes a brain to activate its shield. Instead, shoot in small bursts, or team up with another player and shoot two different kinds of attacks at once.